in IE it is a bit fussy when it comes to spaces and placing of things. try this...
<HTML>
<HEAD>
<META NAME="Author" CONTENT="">
<META NAME="Generator" CONTENT="Jasc Paint Shop Pro 8">
<TITLE> </TITLE>
</HEAD>
<BODY>
<MAP NAME="Image14_2x3">
<AREA SHAPE="rect" COORDS="21,10,104,41" HREF="http://basix.com" TARGET="iframe">
<AREA SHAPE="rect" COORDS="27,42,93,66" HREF="http://post.com" TARGET="iframe">
<AREA SHAPE="rect" COORDS="30,68,95,93" HREF="http://bio.com" TARGET="iframe">
<AREA SHAPE="rect" COORDS="12,93,120,123" HREF="http://graph.com" TARGET="iframe">
<AREA SHAPE="rect" COORDS="12,124,126,151" HREF="http://tut.com" TARGET="iframe">
<AREA SHAPE="rect" COORDS="28,153,107,178" HREF="http://other.com" TARGET="iframe">
</MAP>
<CENTER>
<!-- Begin Table -->
<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="600" HEIGHT="503"><TR>
<TD ROWSPAN="1" COLSPAN="3" WIDTH="600" HEIGHT="58"><IMG NAME="Image140" SRC="http://h1.ripway.com/slidinglassx/Folder%20Name/Image14_1x1.png" WIDTH="600" HEIGHT="58" BORDER="0"></TD>
</TR><TR>
<TD ROWSPAN="2" COLSPAN="1" WIDTH="27" HEIGHT="445"><IMG NAME="Image141" SRC="http://h1.ripway.com/slidinglassx/Folder%20Name/Image14_2x1.png" WIDTH="27" HEIGHT="445" BORDER="0"></TD>
<TD ROWSPAN="1" COLSPAN="1" WIDTH="433" HEIGHT="415"><iframe src="main.html" width="433" height="415" frameborder="0" name="iframe"></iframe></TD>
<TD ROWSPAN="1" COLSPAN="1" WIDTH="140" HEIGHT="415"><IMG NAME="Image14_2x30" SRC="http://h1.ripway.com/slidinglassx/Folder%20Name/Image14_2x3.png" WIDTH="140" HEIGHT="415" BORDER="0" USEMAP="#Image14_2x3"></TD>
</TR><TR>
<TD ROWSPAN="1" COLSPAN="2" WIDTH="573" HEIGHT="30"><IMG NAME="Image144" SRC="http://h1.ripway.com/slidinglassx/Folder%20Name/Image14_3x1.png" WIDTH="573" HEIGHT="30" BORDER="0"></TD>
</TR></TABLE>
<!-- End Table -->
</CENTER>
</BODY>
</HTML>
(you can take out the full URL of the images, just had to do that so i could test it out)